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KMID : 1141520230380050482
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Endocrinology and Metabolism
2023 Volume.38 No. 5 p.482 ~ p.492
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The Impact of Taurine on Obesity-Induced Diabetes Mellitus: Mechanisms Underlying Its Effect
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Kainat Ahmed
Choi Ha-Neul
Yim Jung-Eun
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Abstract
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This review explores the potential benefits of taurine in ameliorating the metabolic disorders of obesity and type 2 diabetes (T2D), highlighting the factors that bridge these associations. Relevant articles and studies were reviewed to conduct a comprehensive analysis of the relationship between obesity and the development of T2D and the effect of taurine on those conditions. The loss of normal β-cell function and development of T2D are associated with obesity-derived insulin resistance. The occurrence of diabetes has been linked to the low bioavailability of taurine, which plays critical roles in normal β-cell function, anti-oxidation, and anti-inflammation. The relationships among obesity, insulin resistance, β-cell dysfunction, and T2D are complex and intertwined. Taurine may play a role in ameliorating these metabolic disorders through different pathways, but further research is needed to fully understand its effects and potential as a therapeutic intervention.
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KEYWORD
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Diabetes complications, Taurine, Obesity, Inflammation, Beta-cell dysfunction
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